Seraphina Laurent a modern-day nurse and guérisseuse, collapses during a visit to the Weld House Civil War Medicine exhibit, only to awaken in 1862, Virginia.

Out of place and time, Seraphina confronts the brutal realities of slavery and war. Drawing on her Creole healing heritage, she begins treating runaway slaves and wounded soldiers on a contraband farm tucked behind Union lines.

Colonel Dr. Aaron Weld, Union surgeon, overwhelmed by the endless tide of the wounded, fears the war will be lost in the hospitals, not on the battlefield. When rumors spread of a mysterious Black woman healing men thought dead, he sets out to find her.

What he finds is Seraphina. Captivated by her beauty and baffled by her advanced medical skills, Aaron enlists her help, pulling her into the relentless world of Civil War medicine. Sparks fly as Seraphina clashes with his rigid discipline, but their undeniable chemistry soon threatens to ignite something neither unexpected. Aaron is torn between duty and desire. Seraphina resists the pull of the handsome colonel, but fate has its plans.